科学研究

科学研究 学术动态

【学术活动预告】BMP信号对肠上皮的稳态调控

报告人:陈晔光 院士,清华大学

报告时间:2017年12月22日(星期五)下午13:30

报告地点:生命科学学院3楼大报告厅

主办单位:生命科学学院

陈晔光院士简介

江西乐安人。博士,清华大学教授、博士生导师,国家“杰出青年基金”获得者、“长江学者奖励计划”特聘教授。2017年11月,当选中国科学院院士。

学习经历

1979-1983,就读于江西大学(今南昌大学)生物系,获生物学学士学位。

1983-1986,就读于江西大学生物系,获动物学硕士学位。

1988-1990,就读于Fordham University,获细胞生物学硕士学位。

1991-1996,就读于美国Albert Einstein College of Medicine,获Ph.D.学位。

1996-2000, Post-doctoral Research Associate, Memorial Sloan-Kettering Cancer Center/Howard Hughes Medical Institute.

2000-2002, Assistant Professor, University of California, Riverside.

任职经历

2002-至今,清华大学教授。

科研领域

细胞信号转导:利用分子生物学、生物化学及细胞生物学等多学科技术手段研究TGF-β受体的调控、TGF-β和Wnt在肿瘤形成及血管形成中的作用。

代表论文

Selected Publications:

1. Zuo W, Huang F, Chiang YJ, Li M, Du J, Ding Y, Zhang T, Lee HW, Jeong LS, Chen Y, Deng H, Feng XH, Luo S, Gao C, Chen YG 2013 c-Cbl-mediated neddylation antagonizes ubiquitination and degradation of the TGF-β type II receptor. Molecular Cell, 49(3):499-510.

2. Li Z, Fei1 T, Zhang J, Zhu G, Wang L, Lu D, Chi X, Teng Y, Hou N, Yang X, Zhang H, Han JD, Chen YG 2012 BMP4 signaling acts via Dual Specificity Phosphatase 9 to control ERK activity in mouse embryonic stem cells. Cell Stem Cell, 10:171-182.

3. Zhao B, Wang Q, Du J, Luo S, Xia J, Chen YG 2012 PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Cell Research, 22:1467-1478.

4. Gao C, Cao W, Bao W, Zuo W, Xie G, Cai T, Fu W, Zhang J, Wu W, Zhang X, Chen YG2010 Autophagy negatively regulates Wnt signaling by promoting Dishevelled degradation. Nature Cell Biology, 12:781-790.

5. Fei T, Xia K, Li Z, Zhou B, Zhu S, Chen H, Zhang J, Chen Z, Xiao H, Han JD, Chen YG 2010 Genome-wide Mapping of Smad Target Genes Reveals the Role of BMP Signaling in Embryonic Stem Cell Fate Determination. Genome Research, 20:36-44.

6. Zhang W, Jiang Y, Wang Q, Ma X, Xiao Z, Zuo W, Fang X, Chen YG 2009 Single molecule imaging reveals transforming growth factor-β-induced type II receptor dimerization. Proc Natl Acad Sci. USA, 106:15679-15683.

7. Wang Q, Huang Z, Xue H, Jin C, Ju XL, Han JD, Chen YG 2008 MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood, 111:588-595.

8. Ma J, Wang Q, Fei T, Han JD, Chen YG 2007 MCP-1 mediates TGF-β-induced angiogenesis by stimulating vascular smooth muscle cell migration. Blood, 109:987-994.

■ Chen YG#, Wang Z, Ma J, Zhang L, Lu Z 2007 Endofin, a FYVE domain protein, interacts with Smad4 and facilitates TGF-β signaling. Journal of Biological Chemistry, 282:9688-9695.

■ Huang W, Chang HY, Fei T, Wu H, Chen YG# 2007 GSK3β mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene, 26:2471-2482.

■ Gu Y, Jin P, Zhang L, Zhao X, Gao X, Ning Y, Meng A, Chen YG# 2006 Functional analysis of mutations in the kinase domain of the TGF-β receptor ALK1 reveals different mechanisms for induction of hereditary hemorrhagic telangiectasia. Blood, 107:1951-1954.

■ Zhang L, Gao X, Wen J, Ning Y, Chen YG# 2006 Dapper 1 antagonizes Wnt signaling by promoting Dishevelled degradation. Journal of Biological Chemistry, 381:8607–8612.

■ Zhang, L., Zhou, H., Su, Y., Sun, S., Zhang, H., Zhang, L., Zhang, Y., Ning, Y., Chen, YG# and Meng, A# 2004 Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of Nodal receptors. Science, 306:114-117

■ Lu, Z., Murray, J. T., Luo, W., Li, H., Wu, X., Xu, H., Backer, J. M. and Chen, Y.G# 2002 Transforming growth factor-β activates Smad2 in the absence of receptor endocytosis. Journal of Biological Chemistry, 277:29363-29368.

■ Wu G*, Chen YG*, Ozdamar B, Gyuricza C, Chong PA, Wrana JL, Massagué J, Shi Y. 2000 Structural basis of Smad2 recognition by the Smad Anchor for Receptor Activation. Science. 287:92-97.

■ Massagué, J. and Chen, YG 2000 Controlling TGF-β signaling. Genes & Development, 14:627-644. (Review)

■ Onichtchouk, D*, Chen, YG*, Dosch, R., Gawantka, V., Delius, H., Massagué, J. and Nierhs, C. 1999 Silencing of TGF-β signaling by the pseudoreceptor BAMBI. Nature, 401:480-485.

■ Chen, YG, Hata, A, Lo, R.S., Wotton, D., Shi, Y., Pavletich, N.P. and Massagué, J. 1998 Determinants of specificity in TGF-β signal transduction. Genes & Development, 12:2144-2152.

■ Chen, YG, Liu, F. and Massagué, J. 1997 Mechanism of TGF-β receptor inhibition by FKBP12. EMBO Journal, 16:3866-3876.

发布时间:2017/12/21