科学研究

科学研究 学术动态

【校庆115周年活动学术报道】DNA damage recognition, signaling and repair

5月23日,来自英国牛津大学肿瘤系的Grigory Dianov教授受邀来到南京师范大学生命科学学院做了题为“DNA damage recognition, signaling and repair”的学术报告. Grigory教授用生动的图片和幽默的语言形象地描述了机体所遭遇的各种DNA损伤的类型,以及机体、细胞如何对这些DNA损伤进行应答的过程。他重点围绕DNA损伤修复与细胞周期的关系介绍了自己团队在近年来的工作。在座的老师和同学对Grigory教授的工作表示了浓厚的兴趣,提出了很多问题与其进行了深入的交流与讨论。

EXPERIENCE

1.2007/09-up to now, Oncology department, Oxford Univerity, UK, Professor

2.2000/09-2007/09, MRC Radiation & Genome Stability Unit, Oxon, UK,MRC Senior Group Leader

3.1995/09-2000/09, National Institute on Aging, NIH, Baltimore, USA, Senior Staff Fellow

4.1993/09-1995/09, University of Texas, Dallas, USA, Visiting Associate Professor

5.1990/09-1993/09, Imperial Cancer Research Fund, Clare Hall Laboratories, UK,Senior Research Fellow

6.1987/09-1990/09, Molecular Mechanisms of Mutagenesis, Institute of Cytology and Genetics, Russian Academy of Sciences, Russia,Group Head; Novosibirsk Agricultural Institute, Novosibirsk, Russia,Professor

7.1974/09-1987/09, Laboratory of Molecular Genetics, Institute of Cytology and Genetics, Russian Academy of Sciences, Novosibirsk, Russia,Junior Scientist, Senior Scientist and Principal Scientist

PUBLICATIONS

(1) SophiaX. Pfister, EnniMarkkanen, Yanyan Jiang, SovanSarkar, Mick Woodcock, Giulia Orlando, IoannaMavrommati, Chen-Chun Pai, Lykourgos-PanagiotisZalmas, NeeleDrobnitzky, GrigoryL. Dianov, Clare Verrill, ValentineM. Macaulay, Songmin Ying, NicholasB. LaThangue, Vincenzo D’Angiolella, AndersonJ. Ryan, TimothyC. Humphrey*,Inhibiting WEE1 selectively kills histone H3K36me3-deficient cancers by dNTP starvation, Cancer Cell, 2015, 28:557-568

(2) Svetlana V. Khoronenkova and Grigory L. Dianov*, ATM prevents DSB formation by coordinating SSB repair and cell cycle progression, Proceedings of National academy of Sciences USA, 2015, 112(13):3997-4002

(3) Svetlana V. Khoronenkova, Irina I. Dianova, NicolaTernette, BenediktM. Kessler, JasonL. Parsons,GrigoryL. Dianov*, ATM-Dependent Downregulation of USP7/HAUSP byPPM1G Activates p53 Response to DNA Damage, Mol Cell. 2012, 45:801-813

(4) JasonL. Parsons, IrinaI. Dianova,SvetlanaV. Khoronenkova,MariolaJ. Edelmann,Benedikt M. Kessler,GrigoryL. Dianov*, USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β, Mol Cell, 2011, 41:609-615

发布时间:2017/05/24