科学研究

科学研究 学术动态

【学术活动预告】化学中的催化,我的有机化学之路

 学术预告:化学中的催化,我的有机化学之路

报告人:钟国富 教育部长江学者特聘教授

报告时间:2018117日(周三)下午14:00

地点:化行楼226会议室

钟国富

钟国富教授简介:

博士,杭州师范大学教授,博士研究生导师,教育部长江学者特聘教授

【学习经历】

19799-19837 中国南京理工大学化学化工系 获工学学士 (B.Eng)学位;
1983
9-19867 上海华东理工大学 化学系 获工学硕士 (M.Eng)学位;
1990
10-19957 瑞士洛桑大学 有机化学研究所 获研究证书(Certificate)
1995
8-19985 美国斯克利普斯研究院 获理学博士 (Ph.D.)学位;
1998
5-19993 美国斯克利普斯研究院 获博士后 (postdoc)学位。

【任职经历】
1986
7-19886 上海华东理工大学化学系助教 (Assistant Lecturer);
1988
8-19909 上海华东理工大学化学系讲师 (Lecturer);
1991
8-19956 瑞士洛桑大学化学系助教 (Teaching Assistant);
1995
10-19994 美国斯克利普斯研究院研究员 (Senior Research Associate);
1999
11-200412 美国斯克利普斯研究院助理教授 (Assiatant Professor);
2005
1-20061 复旦大学生物医学研究院杰出PI (Outstanding Principal Investigator);
2005
1-20061 复旦大学化学系,有机化学研究所长江特聘教授 (Changjiang Professor)、所长 (Director);
2006
1-20118 新加坡南洋理工大学 化学与生物化学系副教授 (Associate Professor);
2011
9-至今 杭州师范大学教授。

【主要研究方向】

从事有机化学、不对称催化和药物化学等方面的研究。

【代表性论著】

  1. “Core Structure-Based Design of Organocatalytic [3+2]-Cycloaddition Reactions: Highly Efficient and Stereocontrolled Syntheses of 3,3 '-Pyrrolidonyl Spirooxindoles”, B. Tan, X. Zeng, W. W. Y. Leong, Z. Shi, C. F. Barbas III,* G. Zhong,* Chem. - Eur. J. 201218, 61.

2. “Chiral Brønsted Acid Catalyzed Enantioselective alpha-Aminoxylation of Enecarbamates”, M. Lu, Y. Lu, D. Zhu, X. Zeng, X. Li, G. Zhong,* Angew. Chem., Int. Ed. 201049, 8588.

3. “Catalytic Asymmetric Formal [4+1] Annulation Leading to Optically Active cis-Isoxazoline N-Oxides”, Z. Shi, B. Tan, W. W. Y. Leong, X. Zeng, M. Lu, G. Zhong,* Org. Lett. 201012, 5402.

4. “Highly Stereoselective Synthesis of Indanes with Four Stereogenic Centers via Sequential Michael Reaction and [3+2] Cycloaddition”, P. J. Chua, B. Tan, L. Yang, X. Zeng, D. Zhu, G. Zhong,* Chem. Commun. 201046, 7611.

5. “Facile Domino Access to Chiral Bicyclo[3.2.1]octanes and Discovery of a New Catalytic Activation Mode”, B. Tan, Y. Lu, X. Zeng, P. J. Chua, G. Zhong,*Org. Lett. 201012, 2682.

6. “Chiral Bronsted Acid Catalyzed Enantioselective Addition of alpha-Isocyanoacetamides to Aldehydes”, X. Zeng, K. Ye, M. Lu, P. J. Chua, B. Tan, G. Zhong,* Org. Lett. 201012, 2414.

7. “Diastereoselective HOTf-catalyzed Three-component One-pot 1,3-Dipolar Cycloaddition of Diazo Ester, Nitrosobenzene and Electron-deficient Alkene”, Z.-J. Xu, D. Zhu, X. Zeng, F. Wang, B. Tan, Y. Hou, Y. Lv, G. Zhong,* Chem. Commun.201046, 2504.

8. “Water More than Just a Green Solvent: A Stereoselective One-Pot Access to All Chiral Tetrahydronaphthalenes in Aqueous Media”, B. Tan, D. Zhu, L. Zhang, P. J. Chua, X. Zeng, G. Zhong,* Chem. - Eur. J. 201016, 3842.

9. “Organocatalytic Asymmetric Synthesis of Protected alpha,beta-Diamino Acids”, Z. Shi, P. Yu, P. J. Chua, G. Zhong,* Adv. Synth. Catal. 2009351, 2797.

10. “Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis”, H. Sun, R. Kong, D. Zhu, M. Lu, Q. Ji, C. W. Liew, J. Lescar, G. Zhong,* Z.-X. Liang,* Chem. Commun. 2009, 7399. 

11. “Highly Stereoselective One-Pot Synthesis of Bicyclic Isoxazolidines with Five Stereogenic Centers by an Organocatalytic Process”, D. Zhu, M. Lu, L. Dai, G. Zhong,* Angew. Chem., Int. Ed. 200948, 6089.

12. “Highly Efficient Asymmetric Trans-Selective Aziridination of Diazoacetamides and N-Boc-imines Catalyzed by Chiral Brønsted Acids”, X. Zeng, X. Zeng, Z. Xu, M. Lu, G. Zhong,* Org. Lett. 200911, 3036.

13. “Chiral Brønsted Acid-Catalyzed Enantioselective alpha-Hydroxylation of beta-Dicarbonyl Compounds”, M. Lu, D. Zhu, Y. Lu, X. Zeng, B. Tan, Z. Xu, G. Zhong,* J. Am. Chem. Soc. 2009131, 4562. 

14. “Unusual Domino Michael/Aldol Condensation Reactions Employing Oximes as N-Selective Nucleophiles: Synthesis of N-Hydroxypyrroles”, B. Tan, Z. Shi, P. J. Chua, Y. Li, G. Zhong,* Angew. Chem., Int. Ed. 200948, 758. 

15. “Rational Design of Organocatalyst: Highly Stereoselective Michael Addition of Cyclic Ketones to Nitroolefins”, B. Tan, X. Zeng, Y. Lu, P. J. Chua, G. Zhong,* Org. Lett. 200911, 1927.   

16. “Recyclable organocatalysis: Highly enantioselective Michael addition of 1,3-diaryl-1,3propanedione to nitroolefins¡”, B. Tan, X. Zhang, P. J. Chua, G. Zhong,* Chem. Commun. 2009, 779. 

17. “An Unexpected N-Heterocyclic Carbene-Catalyzed Annulation of Enals and Nitroso Compounds”, L. Yang, B. Tan, F. Wang, G. Zhong,* J. Org. Chem. 200974, 1744.   

18. “Highly enantioselective L-thiaproline catalyzed alpha-aminoxylation of aldehydes in aqueous Media”, P. J. Chua, B. Tan, G. Zhong,* Green Chem. 200911, 543.  

19. “Organocatalytic Asymmetric Domino ¦Á-Aminoxylation/Aza-Michael Reactions for the Synthesis of Functionalized Tetrahydro-1,2-oxazines”, M. Lu, D. Zhu, Y. Lu, Y. Hou, B. Tan, G. Zhong,* Angew. Chem., Int. Ed. 200847, 10187.  

20. “A Highly Stereoselective Organocatalytic Tandem Aminoxylation/Aza-Michael Reaction for the Synthesis of Tetrahydro-1,2-Oxazines”, D. Zhu, M. Lu, P. J. Chua, B. Tan, F. Wang, X. Yang, G. Zhong,* Org. Lett. 200810, 4585.  

21. “A Highly Diastereo- and Enantioselective Synthesis of Multisubstituted Cyclopentanes with Four Chiral Carbons by the Organocatalytic Domino Michael-Henry Reaction”, B. Tan, P. J. Chua, X. Zeng, M. Lu, G. Zhong,* Org. Lett. 200810, 3489.  

22. “Control of Four Stereocenters in an Organocatalytic Domino Double Michael Reaction: Efficient Synthesis of Multisubstituted Cyclopentanes”, B. Tan, Z. Shi, P. J. Chua, G. Zhong,* Org. Lett. 200810, 3425. 

23. “Organocatalytic Asymmetric Tandem Michael-Henry Reactions: A Highly Stereoselective Synthesis of Multifunctionalized Cyclohexanes with Two Quaternary Stereocenters”, B. Tan, P. J. Chua, Y. Li, G. Zhong,* Org. Lett. 200810, 2437.

发布时间:2018/01/09